Top Diversified Bank Companies To Own In Right Now: Merrimack Pharmaceuticals Inc (MACK)
Merrimack Pharmaceuticals, Inc., incorporated in 1993, is a biopharmaceutical company discovering, developing and preparing to commercialize medicines paired with companion diagnostics for the treatment of serious diseases, with an initial focus on cancer. The Company�� product candidates include MM-398, MM-121, MM-111, MM-302 and MM-151. As of June 31, 2011, the Company owned approximately 74% interest of Silver Creek.
The Company�� Network biology is an interdisciplinary approach to drug discovery and development that enables the Company to build functional and predictive computational models of biological systems based on quantitative, kinetic, multiplexed biological data. The Company provides its scientists with insights into how the complex molecular interactions that occur within cell signaling pathways, or networks, regulate cell decisions and how dysfunction within these networks leads to disease. The Company applies network biology throughout the research and development process, including for target identification, lead compound design and optimization, diagnostic discovery, in vitro and in vivo predictive development and the design of clinical trial protocols.
MM-398
MM-398 is a stable nanotherapeutic encapsulation, or enclosed sphere carrying an active drug, of the marketed chemotherapy drug irinotecan. MM-398 achieved its primary efficacy endpoints in Phase 2 clinical trials in pancreatic and gastric cancer. In an open label, single arm Phase 2 clinical trial of MM-398 as a monotherapy in 40 metastatic pancreatic cancer patients who had previously failed treatment with gemcitabine, patients treated with MM-398 achieved median overall survival of 22.4 weeks. Additionally, 20% of the patients in this Phase 2 trial survived for more than one year, and the Company observed a disease control rate, meaning patients exhibited stable disease or partial or complete response to treatment, of 47.5% at six weeks.
The Company focuses on initiati! ng a Phase 3 clinical trial of MM-398 for the treatment of patients with metastatic pancreatic cancer who have previously failed treatment with gemcitabine. The trial is expected to enroll approximately 250 patients and is designed to compare the efficacy of MM-398 as a monotherapy against the combination of the chemotherapy drugs fluorouracil, or 5-FU, and leucovorin. There are multiple ongoing Phase 1 and Phase 2 clinical trials of MM-398. In July 2011, the United States Food and Drug Administration (FDA) granted MM-398 orphan drug designation for the treatment of pancreatic cancer.
MM-121
MM-121 is a fully human monoclonal antibody that targets ErbB3, a cell surface receptor, or protein attached to the cell membrane that mediates communication inside and outside the cell, that the Company�� network biology approach identified as a target in a range of cancers. A monoclonal antibody is a type of protein normally produced by cells of the immune system that binds to just one epitope, or chemical structure, on a protein or other structure. MM-121 is designed to inhibit cancer growth directly, restore sensitivity to drugs to which a tumor has become resistant and delay the development of resistance of a tumor to other agents. In collaboration with Sanofi, the Company focuses on testing MM-121 in combination with both chemotherapies and other targeted agents across a range of spectrum of solid tumors, including lung, breast and ovarian cancers. The Company partnered MM-121 with Sanofi after it initiated Phase 1 clinical development of the product candidate.
MM-111
MM-111 is a bispecific antibody designed to target cancer cells that are characterized by overexpression of the ErbB2 cell surface receptor, also referred to as HER2. A bispecific antibody is a type of antibody that is able to bind simultaneously to two distinct proteins or epitopes. The Company�� network biology approach identified that ligand-induced signaling through the complex of ErbB2 ! (HER2) an! d ErbB3 is a promoter of tumor growth and survival than previously appreciated.
MM-302
MM-302 is a nanotherapeutic encapsulation of doxorubicin with attached antibodies that are designed to target MM-302 to cells that over express the ErbB2 (HER2) receptor. The Company is conducting a Phase 1 clinical trial of MM-302 in patients with advanced ErbB2 (HER2) positive breast cancer.
MM-151
MM-151 is an oligoclonal therapeutic consisting of a mixture of three fully human monoclonal antibodies designed to bind to non-overlapping epitopes of the epidermal growth factor receptor (EGFR). EGFR is also known as ErbB1. An oligoclonal therapeutic is a mixture of two or more distinct monoclonal antibodies. The Company has designed MM-151 to block signal amplification that occurs within the ErbB cell signaling network. The Company has submitted an investigational new drug application (IND), to the FDA for MM-151 in July 2011.
Advisors' Opinion:- [By Maria Armental var popups = dojo.query(".socialByline .popC"); popups.forEach]
Merrimack Pharmaceuticals Inc.(MACK) and Sanofi (SAN.FR) have ended their license and collaboration agreement for the development and commercialization of Merrimack’s antibody MM-121 to treat several forms of cancer. Merrimack dropped 10% to $7.07 premarket.
Top Diversified Bank Companies To Own In Right Now: Kemper Corp (KMPR)
Kemper Corporation (Kemper), formerly Unitrin, Inc., incorporated in 1990, is a diversified insurance holding company, with subsidiaries that provide life, health, automobile, homeowners and other insurance products to individuals and small businesses. The Company is engaged, through its subsidiaries, in the property and casualty insurance, life and health insurance and automobile finance businesses. The Company conducts its operations through four operating segments: Kemper Preferred (Preferred), Unitrin Specialty (Specialty), Unitrin Direct (Direct) and Life and Health Insurance. On September 14, 2011, its subsidiary, Fireside Bank sold its loan portfolio to a subsidiary of Consumer Portfolio Services, Inc.
Property and Casualty Insurance Business
The Company's property and casualty insurance business operations are primarily conducted through the Preferred, Specialty and Direct segments. In addition, the Life and Health Insurance segment�� career agents also sell property insurance to its customers. Its insurance subsidiaries operating in the Preferred, Specialty and Direct segments provide automobile, homeowners, fire, and other types of property and casualty insurance to individuals and commercial automobile insurance to businesses. During the year ended December 31, 2011, automobile insurance in these segments accounted for 54% of its consolidated insurance premiums earned from continuing operations, and 47% of its consolidated revenues from continuing operations. During 2011, homeowners insurance in these segments accounted for 14% of its consolidated insurance premiums earned from continuing operations, and 11% of its consolidated revenues from continuing operations.
Preferred and Specialty segments distribute their products through independent agents who are paid commissions for their services. Direct segment distributes its products directly to consumers and through employer-sponsored voluntary benefit programs and other affinity relationships.! Preferred, based in Jacksonville, Florida, conducts business in 38 states and the District of Columbia. During 2011, the states, which provided over half of the premium revenues in Preferred segment included New York (19%), California (12%), North Carolina (13%) and Texas (10%). Preferred segment primarily sells preferred and standard risk automobile and homeowners insurance. During 2011, Preferred�� insurance products accounted for 53% of the aggregate insurance premium revenues of the Company�� property and casualty insurance business. Its products are marketed by approximately 2,700 independent insurance agents. Specialty, based in Dallas, Texas, conducts business in 21 states, principally in the southwest and western United States. During 2011, the states, which provided more than three-fourths of the premium revenues in Specialty segment included California (42%), Texas (18%), Washington (8%), Louisiana (4%) and Oregon (3%). Specialty provides personal and commercial automobile insurance. During 2011, Specialty�� insurance products accounted for 28% of the aggregate insurance premium revenues of the Company�� property and casualty insurance business. Specialty�� products are marketed through approximately 8,000 independent agents and brokers.
Direct, based in Chicago, Illinois, markets personal automobile, homeowners and renters insurance through a range of direct-to-consumer Websites, including its own Websites, marketing partners, employer and other affinity-sponsored relationships. The Direct segment�� automobile insurance products are available in 48 states and the District of Columbia. During 2011, the states, which provided approximately two-thirds of the premium revenues in Unitrin Direct segment included Florida (12%), New York (15%), California (10%), Texas (5%), Connecticut (5%), Michigan (8%), Pennsylvania (5%) and Georgia (5%). During 2011, Direct�� insurance products accounted for 14% of the aggregate insurance premium revenues of its property and casualty i! nsurance ! business.. Direct also offers homeowners and renters insurance across 47states and the District of Columbia, complementing its direct automobile insurance business. The Company manages its exposure to catastrophes and other natural disasters through a combination of geographical diversification, restrictions on the amount and location of new business production in certain regions, and reinsurance. To limit its exposures to catastrophic events, the Company maintains various primary catastrophe reinsurance programs for its property and casualty insurance businesses.
Life and Health Insurance Business
The Company�� Life and Health Insurance segment consists of Kemper�� wholly owned subsidiaries, United Insurance Company of America (United Insurance), The Reliable Life Insurance Company (Reliable), Union National Life Insurance Company (Union National Life), Mutual Savings Life Insurance Company (Mutual Savings Life), United Casualty Insurance Company of America (United Casualty), Union National Fire Insurance Company (Union National Fire), Mutual Savings Fire Insurance Company (Mutual Savings Fire) and Reserve National Insurance Company (Reserve National). As discussed below, United Insurance, Reliable, Union National Life, Mutual Savings Life, United Casualty, Union National Fire and Mutual Savings Fire (the Kemper Home Service Companies) distribute their products through a network of employee, or career, agents. Reserve National distributes its products through a network of exclusive independent agents. Both these career agents and independent agents are paid commissions for their services. During 2011, the states, which provided approximately two-thirds of the Life and Health Insurance segment�� premium revenues included Texas (21%), Louisiana (11%), Alabama (7%), Mississippi (6%), Illinois (4%), Florida (4%), Georgia (4%), Missouri (4%), and North Carolina (4%). During 2011, life insurance accounted for 18% of the Company�� consolidated insurance premiums earned from ! continuing! operations, and 16% of its consolidated revenues from continuing operations.
The Kemper Home Service Companies, based in St. Louis, Missouri, focus on providing individual life and health insurance products to customers of modest incomes who desire basic protection for themselves and their families. Their product is ordinary life insurance, including permanent and term insurance. Face amounts of these policies are lower than those of policies sold to higher income customers by other companies in the life insurance industry. Approximately 79% of the Life and Health Insurance segment�� premium revenues are generated by the Kemper Home Service Companies. The Life and Health Insurance segment�� career agents also distribute certain property insurance products. Reserve National, based in Oklahoma City, Oklahoma, is licensed in 35 states throughout the south, southwest and midwest, and specializes in the sale of Medicare Supplement insurance and limited health insurance coverages, such as fixed indemnity, dental and vision, and accident-only plans, primarily to individuals in rural areas where access to a multitude of health plan options is less prevalent.
The Company's life and health insurance companies utilize reinsurance arrangements. Included among the segment�� reinsurance arrangements is excess of loss reinsurance coverage specifically designed to protect against losses arising from catastrophic events under the property insurance policies distributed by the Kemper Home Service Companies��agents and written by Kemper�� subsidiaries, United Casualty, Union National Fire and Mutual Savings Fire, and reinsured by Kemper�� subsidiary, Trinity Universal Insurance Company (Trinity), or written by Capitol County Mutual Fire Insurance Company (Capitol), a mutual insurance company owned by its policyholders, and its subsidiary, Old Reliable Casualty Company (ORCC), and reinsured by Trinity.
Advisors' Opinion:- [By Rich Duprey]
The property and casualty business of insurance company Kemper� (NYSE: KMPR ) has a new bean counter.
On Monday, the Chicago-based insurance company�announced�that Elizabeth "Libbie" Bock�will take on the role of CFO for the P&C division, where she would be�responsible for all aspects of operations, reporting, control, planning and analysis, financial management, and competitive analysis.
Hot Stocks To Invest In Right Now: Vonage Holdings Corp.(VG)
Vonage Holdings Corp. provides broadband communication services in the United States, Canada, and the United Kingdom. The company offers voice and messaging services through session initiation protocol (SIP) based voice over Internet protocol network. The company?s primary product offering is Vonage World, a residential plan with unlimited calling domestically and to approximately 60 countries, including India, Mexico, and China for a flat monthly rate. It also provides broadband telephone replacement services to residential, small office, and home office customers through various service plans with a range of basic features, including call waiting, caller ID with name, call forwarding, and voicemail. In addition, the company offers mobile services through mobile applications that can be downloaded for iPhone, iPad, iPod touch, and Android OS devices. Further, the company provides Vonage Mobile, a free downloadable mobile application that provides free calling and messagi ng between users who have the application, as well as traditional paid international calling to any other phone. It markets its services through in-bound telemarketing and online direct sales, as well as through regional and national retailers. As of December 31, 2011, the company had approximately 2.4 million subscriber lines. Vonage Holdings Corp. was incorporated in 2000 and is headquartered in Holmdel, New Jersey.
Advisors' Opinion:- [By Alex Planes]
Investors love stocks that consistently beat the Street without getting ahead of their fundamentals and risking a meltdown. The best stocks offer sustainable market-beating gains, with robust and improving financial metrics that support strong price growth. Does Vonage Holdings (NYSE: VG ) fit the bill? Let's take a look at what its recent results tell us about its potential for future gains.
- [By Luke Jacobi]
Vonage Holdings (NYSE: VG) was down as well, dropping almost five percent to $3.53 despite seemingly little news into the end of trading.
Global markets
Top Diversified Bank Companies To Own In Right Now: Avis Budget Group Inc.(CAR)
Avis Budget Group, Inc., together with its subsidiaries, provides car and truck rentals, and ancillary services to businesses and consumers worldwide. It supplies rental cars to the premium commercial and leisure segments of the travel industry under the Avis brand; and to the value-conscious segments of the industry under the Budget brand. The company operates or licenses the Avis car rental system that includes approximately 5,200 locations; and operates approximately 2,100 Avis car rental locations in on-airport and local rental markets; and operates or licenses the Budget vehicle rental system comprising approximately 3,050 car rental locations, and operates approximately 1,100 Budget car rental locations. It also operates local and one-way truck rental businesses, and operates a combined fleet of approximately 26,000 trucks, which are rented through a network of approximately 1,850 dealers and 300 company-operated locations in the continental United States serving the consumer and light commercial sectors. In addition, the company engages in the sale and rental of optional products and services, including loss damage waivers; insurance products, such as additional/supplemental liability insurance or personal accident/effects insurance; automobile towing equipment and other moving accessories consisting of hand trucks, furniture pads, and moving supplies; and products for driving convenience, such as where2 GPS navigation units, optional roadside assistance, fuel service options, and electronic toll collection, as well as other ancillary products and services comprising rental of satellite radio units and child safety seats. Its rental fleet comprises approximately 393,000 vehicles. The company was formerly known as Cendant Corporation. Avis Budget Group, Inc. was founded in 1946 and is headquartered in Parsippany, New Jersey.
Advisors' Opinion:- [By Rick Aristotle Munarriz]
Mel Evans/AP From a media giant growing its reach through rental cars to a beleaguered theme park operator warning of even slower turnstile clicks, here's a rundown of the week's best and worst from the business world. Microsoft (MSFT) -- Winner Many argued that Microsoft deciding late last month to offer up its flagship Microsoft Office suite of productivity software for iPads was too little, too late. Folks had already moved on to free or nearly free alternatives, and Microsoft was already suffering with a global slump in PC sales. Well, Microsoft still has plenty of bite. It announced there were 12 million downloads of its Word, Excel and PowerPoint iPad apps in its first week of availability. Barnes & Noble (BKS) -- Loser It's not just bookworms checking out of Barnes & Noble. Liberty Media (LMCA) is selling 90 percent of its shares of the struggling bookstore operator, taking its stake of 17 percent down to less than 2 percent. Liberty Media will give up the right to appoint a pair of board members now that it's a shrinking investor, but that seems to be a small price to pay for an investor that wants to deploy that money somewhere else. Running a book superstore isn't easy these days. Barnes & Noble's sales have been sluggish as readers go digital, and the chain's push to cash in on the trend with its own Nook line is fading fast. Sirius XM Radio (SIRI) -- Winner Satellite radio will be easier to tune into in rental cars. Avis Budget Group (CAR) revealed this week that in-dash Sirius XM receivers are now available in more than 60 percent of its Avis and Budget car rental agencies. Avis Budget previously relied on portable plug-and-play receivers that renters could order at the counter. Drivers will still have to pay for access. There's no free lunch even if it's a prepaid rental. However, it's still a good way for Sirius XM to expand brand awareness and ideally hook future subscribers. SeaWorld (SEAS) -- Loser Looks like the killer
- [By Jon C. Ogg]
Avis Budget Group, Inc. (NYSE: CAR) is an obvious winner, particularly after selling off more than 4% on Tuesday. That is now down 20% from its highs. If car rental rates are up 30% and they still are�mostly sold out, that is called a license to gouge. If you are traveling around and need to drive, hitchhiking is not legal in many places now.
- [By Ben Levisohn]
Unlike other companies that have been targeted by activists–we’re looking at you Abercrombie & Fitch (ANF)–this has been a very good year for Hertz Global and its competitor Avis Budget Group (CAR). Hertz is up 73%, while Avis has more than doubled. So MKM Partners’ Christopher Agnew and Bradford Dalinka can see the logic in the “poison pill:”
- [By Lisa Levin]
Avis Budget Group (NASDAQ: CAR) shares touched a new 52-week high of $41.03. Avis Budget shares have jumped 94.61% over the past 52 weeks, while the S&P 500 index has gained 24.92% in the same period.
Top Diversified Bank Companies To Own In Right Now: Whole Foods Market Inc.(WFM)
Whole Foods Market, Inc. engages in the ownership and operation of natural and organic food supermarkets. The company offers produce, seafood, grocery, meat and poultry, bakery, prepared foods and catering, coffee and tea, nutritional supplements, and vitamins. It also provides specialty products, such as beer, wine, and cheese; body care and educational products, such as books; and floral, pet, and household products. As of February 9, 2011, the company operated 302 stores in the United States, Canada, and the United Kingdom. Whole Foods Market, Inc. was founded in 1978 and is headquartered in Austin, Texas.
Advisors' Opinion:- [By James E. Brumley]
Quick, what do Wal-Mart Stores, Inc. (NYSE:WMT), Whole Foods Market, Inc. (NASDAQ:WFM), and Jamba, Inc. (NASDAQ:JMBA) - the purveyor of Jamba Juice smoothie shops - have in common? They're all three offering at least one product from KonaRed Corp. (OTCBB:KRED). All told, KRED products can be found in a variety of retail outlets, ranging from mass marketers like WMT to niche players like WFM to service providers like JMBA to convenience stores like 7-Eleven to grocers like Albertson's to.... well, the point becomes clear. KonaRed is in a lot of places. Yet, the number of spots where a KRED could multiply by eight by the middle of the year. In fact, the organization's growth rate is the most exciting - and perhaps most understated - aspect of the KonaRed story.
- [By David Hanson]
7. Whole Foods Market (NASDAQ: WFM ) Whole Foods Market is often jokingly labeled "Whole Paycheck" because of its steeper-than-average grocery prices. Similarly, the company's stock price also sports a high price tag. Despite trading over 10% lower than its all-time high, the stock still trades at almost 34 times trailing earnings. The grocer's fiercely loyal customer base and brand power are not compelling enough for Buffett to pay up for shares of the leader in a historically low-margin industry.
- [By Joe Tenebruso and Richard Engdahl]
Is Whole Foods (NASDAQ: WFM ) a culinary destination? Is it a neighborhood bar? Is it a lifestyle? Or is it just a fancy-pants grocery store that's trying too hard?�
- [By Tess Stynes var popups = dojo.query(".socialByline .popC"); popups.forEach(fu]
Among the companies with shares expected to actively trade in Wednesday’s session are Mondelez International Inc.(MDLZ), Whole Foods Market Inc.(WFM) and AOL Inc.(AOL)
Top Diversified Bank Companies To Own In Right Now: Woolworths Ltd (WOW)
Woolworths Limited is an Australia-based company. The Company operates in five segments: Australian Food and Liquor, New Zealand Supermarkets, Petrol, BIG W and Hotels. Australian Food and Liquor segment is engaged in the procurement of food and liquor and products for resale to customers in Australia. New Zealand Supermarkets segment is engaged in the procurement of food and liquor and products for resale to customers in New Zealand. Petrol segment is engaged in the procurement of petroleum products for resale to customers in Australia. BIG W segment is engaged procurement of discount general merchandise products for resale to customers in Australia. Hotels segment is engaged in the provision of leisure and hospitality services, including food and alcohol, accommodation, entertainment and gaming. Advisors' Opinion:- [By Jonathan Burgos]
Woolworths Ltd. (WOW) dropped 1.6 percent to A$33.22 after Australia�� largest retailer said challenging economic condition were evident in the second quarter.
Top Diversified Bank Companies To Own In Right Now: Cooper Tire & Rubber Company(CTB)
Cooper Tire & Rubber Company, together with its subsidiaries, manufactures and markets replacement tires in North America and internationally. It operates in two segments, North American Tire Operations and International Tire Operations. The North American Tire Operations segment produces and distributes passenger car and light truck tires, as well as tires for racing, medium trucks, and motorcycles to independent tire dealers, wholesale distributors, regional and national retail tire chains, and other large automotive product retail chains. This segment sells its products through three own retail stores. The International Tire Operations segment manufactures and markets passenger car, light truck, motorcycle, light vehicle tires, radial and bias medium truck tires, and racing tires and tire retread material to markets worldwide. The company was founded in 1913 and is based in Findlay, Ohio.
Advisors' Opinion:- [By Jake L'Ecuyer]
Cooper Tire & Rubber Co (NYSE: CTB) was down, falling 12.40 percent to $25.85 on news that its deal with Apollo appears to be in jeopardy.
Commodities
In commodity news, oil traded down 0.81 percent to $103.00, while gold traded up 0.95 percent to $1,322.40. Silver traded up 2.62 percent Monday to $22.30, while copper fell 0.11 percent to $3.30. - [By Luke Jacobi]
Cooper Tire & Rubber Co (NYSE: CTB) fell 12.84 percent to close at $25.72 on news that its deal with Apollo appears to be in jeopardy.
Commodities
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